Rune's Pharmacy ~Tiara's Pharmacist

Left with her parents' pharmacy on the quiet Tiara Island, Erunelle Odette also inherits a debt she had no part in creating. Now she's a novice pharmacist with barely enough skill to fill a prescription, a creditor named Sharvan from the Balfolle company showing up at her door, and the pressure of keeping her family's legacy alive pressing down on her shoulders. The setup is grounded for a fantasy: gather rare ingredients, learn complex recipes, serve the island's people, and somehow make enough coin to stay afloat. There's a real texture to the potion-making side of things — if you're into the craft and economy of pharmacy fantasy like Parallel World Pharmacy or Drugstore in Another World: The Slow Life of a Cheat Pharmacist, that thread is here. The economic struggle angle also has shades of Maoyuu Maou Yuusha in how it grounds magical settings in practical stakes. Worth being upfront: this is a 4-episode ONA from 2018 with adult content woven into the story, so it's not the same lane as those comparisons tonally. What it does have is a lead character who's genuinely trying to earn her footing rather than stumbling into power, and a small-scale island setting that keeps things personal. If that combination of fantasy world-building, debt-driven stakes, and adult content sounds like your thing, it's a short watch.