What a nice conclusion to their story! It comes full circle back to Dr Ramune, he was the one that saved Kuro with his drastic treatment plans, but in this episode, Kuro and all his other patients, comes back to help him with his internal turmoil. I would say, this anime, albeit simple, have lots of deep and touching topics, and all the mysterious disease are very unique, sometimes gore, but the messages are all very good. Give it a try, by the end you might end up feeling sad that it actually ended because you've grown attached to the characters. I would definitely watch this again if they have a second season.